Michael

Manchester United face Brentford without several key players. Kobbie Mainoo (hamstring) is out for a month, Ugarte is on the bench, and Maguire, Mount, Shaw, and Malacia are sidelined.

Porto, defending Taca de Portugal champions, face Sintrense in the third round. Sintrense is in strong form, while Porto seeks a comfortable win despite missing key players. Expect Porto to advance.

Wolfsburg hosts Werder Bremen on Sunday, both aiming to distance from relegation. Wolfsburg sits 12th with 7 points, while Bremen is 11th with 8. Expect a tight match with few chances.

Barcelona hosts Sevilla, aiming for their ninth win of the season. Barcelona leads La Liga with 24 points, while Sevilla is 12th with 12. Expect a strong performance from the hosts.

Villarreal hosts Getafe in La Liga, seeking to rebound after a loss. Villarreal sits 4th with 17 points, while Getafe is 16th with 8. Both teams face injury concerns ahead of the clash.

Atletico Madrid seeks to end a three-match winless run against Leganes in La Liga. Both teams struggle for goals, but Atletico is favored to win, possibly breaking the deadlock in the second half.

Inter visit Roma on Sunday as they resume their Serie A title defense. Roma seek consistency, while Inter, led by in-form Marcus Thuram, aim to extend their unbeaten away run and challenge Napoli at the top.

Napoli visit Empoli on Sunday aiming for a fourth straight win. Empoli, unbeaten at home this season, will be tough opponents. Despite injuries, Napoli's form and firepower make them slight favorites.

Liverpool face Chelsea at Anfield. The Reds, top of the table, aim to stay ahead, while Chelsea seek a win despite key suspensions. A rested Salah and strong defense make Liverpool slight favorites.

Man City visit Wolves, aiming for the top spot. City remain unbeaten while Wolves are on a five-game losing streak. With Haaland leading, expect City to exploit Wolves' defensive issues. Prediction: Wolves 1-4 City.