Mateo Kovacic is set to miss several weeks of action after sustaining an injury while on international duty with Croatia.
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The midfielder has become a key figure in Manchester City’s lineup following Rodri’s season-ending knee injury but now joins the list of sidelined players.
Guardiola confirmed the setback during Friday’s press conference, explaining that Kovacic’s absence comes during a pivotal stretch.
Meanwhile, there is some relief in defence as John Stones, Manuel Akanji, and Nathan Ake return to training, leaving Ruben Dias as the sole injured centre-back.
City will host Tottenham Hotspur on Saturday, aiming to break an unprecedented four-game losing streak under Guardiola.
Losses against Bournemouth, Brighton, and Spurs have left them five points behind in the Premier League title race. Key players like Phil Foden, Jack Grealish, and Jeremy Doku remain doubtful but are hopeful of involvement.