Liverpool faces Southampton at Anfield, with Mohamed Salah expected to shine. This game comes at a perfect time between their Champions League ties against PSG. Alisson will be hoping for a quiet afternoon in goal, while Virgil van Dijk anchors the defense. A Liverpool win looks inevitable as they continue their title charge.
Manchester City visits Nottingham Forest in what could be a tricky fixture. Erling Haaland will be eager to add to his goal tally, while Kevin De Bruyne remains City’s creative force. Forest, led by Morgan Gibbs-White, have been impressive and recently advanced in the FA Cup after a penalty shootout win against Ipswich. Given Forest’s form, a draw seems a strong possibility.
Crystal Palace takes on Ipswich, with Eberechi Eze expected to be a key figure in attack. Palace will be hoping to have Jean-Philippe Mateta available after his injury. Over at the Amex, Brighton faces Fulham in a tough contest, where Kaoru Mitoma and Joao Palhinha could play decisive roles. Home advantage might just give Brighton the win.

Brentford hosts Aston Villa, who will still be feeling the effects of their midweek European win over Club Brugge. Ollie Watkins and Douglas Luiz will be vital for Villa, but fatigue could give Brentford’s Ivan Toney the chance to make an impact and secure a home victory. Meanwhile, Wolves take on Everton without Matheus Cunha, which will be a significant setback. Dominic Calvert-Lewin could be key for Everton, making a draw the most likely result.
Bournemouth travels to Tottenham, with Dominic Solanke in fine form and looking to exploit Spurs’ defensive frailties. James Maddison and Son Heung-min will aim to bounce back after their disappointing Europa League defeat to AZ Alkmaar. Given Bournemouth’s strong season, an away win could be on the cards.
Chelsea faces Leicester at Stamford Bridge, with Cole Palmer and Raheem Sterling expected to lead the attack. Leicester’s recent struggles mean Enzo Fernandez and Moises Caicedo should dominate the midfield battle, making a Chelsea victory the likely outcome.

One of the weekend’s biggest matches sees Arsenal taking on Manchester United at Old Trafford. Bukayo Saka and Martin Odegaard will be crucial for Arsenal, while Bruno Fernandes and Rasmus Hojlund must step up for United. Given Arsenal’s strong form and United’s struggles, an away win looks the most probable result.
Finally, Newcastle faces West Ham in a match where Alexander Isak and Bruno Guimaraes need to deliver. West Ham, led by Jarrod Bowen and Lucas Paqueta, will be tough opponents. However, Newcastle’s good record at the London Stadium could see them snatch an important away win.